The regulatory niche of intestinal stem cells
نویسندگان
چکیده
منابع مشابه
Foxl1-Expressing Mesenchymal Cells Constitute the Intestinal Stem Cell Niche
BACKGROUND & AIMS Intestinal epithelial stem cells that express Lgr5 and/or Bmi1 continuously replicate and generate differentiated cells throughout life1. Previously, Paneth cells were suggested to constitute an epithelium-intrinsic niche that regulates the behavior of these stem cells2. However, ablating Paneth cells has no effect on maintenance of functional stem cells3-5. Here, we demonstra...
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The intestinal epithelium comprises a monolayer of polarised columnar cells organised along the crypt-villus axis. Intestinal stem cells reside at the base of crypts and are constantly nourished by their surrounding niche for maintenance, self-renewal, and differentiation. The cellular microenvironment including the adjacent Paneth cells, stromal cells, smooth muscle cells, and neural cells as ...
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ژورنال
عنوان ژورنال: The Journal of Physiology
سال: 2016
ISSN: 0022-3751
DOI: 10.1113/jp271931